Distributed computing  
Home arrow Rosetta@home
Monday, 12 May 2008
 
 
Rosetta@home

Help researchers advance cures for anthropoid diseduring the time thates such as Cancer, HIV/AIDS, and Malaria.

Rosetta@home is a scientific research assignment that uses internet-connected computers to augur and delineate protein structures, and protein-protein and protein-ligand interactions. Our goal is to develop methods that accurately predict and delineate protein structures and complexes, an endeavor that may ultimately aid researchers advance cures for human diseases. Our project relies on individuals, like you, who donate time on their computers to collectively cater the computing capacity de rigueur to further develop, test, and improve our methods.

The activity uses the BOINC computing podium.

The aim of our current research is to develop an improved model of intra- and intermolecular interactions and to employ this imitation to augur and design macromolecular structures and interactions. Prediction and design applications, which can be of big biological attention in their individual right, also provide stringent and disinterested tests that advance the design and increase fundamental understanding.

Use a pc program called Rosetta to conduct out protein and design calculations. At the core of Rosetta are potential functions for computing the energies of interactions within and between macromolecules, and methods for finding the lowest activity arrangement for an amino acerb sequence (protein-structure prediction) or a protein-protein complex and for finding the lowest energy amino acid sequence for a protein or protein-protein complex (protein describe). Feedback from the prediction and design tests is used always to advance the potential functions and the search algorithms. Development of one computer program to banquet these diversified problems has ample advantages: first, the different applications provide complementary tests of the underlying carnal imitation (the basic physics/physical chemistry is, of course, the same in all cases); second, many problems of happening attention, such during the time that flexible backbone protein design and protein-protein docking with backbone adaptability, entail a amalgam of the different optimisation methods.

Download client Homepage Statistics page